Download full-text PDF. Other full-text Jan [Epub ahead of print] e earliest evidence of portal biliopathy was described by. In EHPVO, there are additional concerns of growth faltering, portal biliopathy, MHE and parenchymal dysfunction. Surgical shunts are Download full-text PDF. Management of portal biliopathy is aimed at biliary decompression and reducing the portal pressure. Portal biliopathy has . Download Figure.

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Bile duct changes caused by portal hypertension represent another group of uncommon causes of benign stricture. The earliest evidence of portal biliopathy was described by Hunt in [1] Download Figure . ePub Link. In EHPVO, there are additional concerns of growth faltering, portal biliopathy, MHE and parenchymal dysfunction. Surgical shunts are . Download high-res image (1MB) · Download full-size image. Fig. 1. Animal [Epub ahead of print]. Results: Portal biliopathy (PB) is a rare complication of extra-portal venous This paper presents 9 of such cases of portal biliopathy, with discussions on their.

Some of the features which are common in cirrhosis, such as jaundice, ascites, and hepatic encephalopathy, are very rare in these patients with normal liver functions and may be seen only after an episode of gastrointestinal hemorrhage.

Large spontaneous shunts protect NCPF patients from variceal bleeding.

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There are some uncommon presentations of NCPF documented in literature, such as glomerulonephritis, hypoxemia due to intrapulmonary shunting, autonomic dysfunction, and fungal brain abscess in a patient with leukopenia due to hypersplenism. Conventional tests of liver function like albumin and prothrombin time are near normal in these patients.

In the study by Dhiman et al. Anemia is common and can be either microcytic hypochromic due to gastrointestinal blood loss, or normocytic normochromic due to hypersplenism.

Leukopenia and thrombocytopenia due to hypersplenism are not uncommon. Though most patients have hypersplenism, they are asymptomatic for the same.

Some patients may present with epistaxis, gum bleeds, and skin petechiae due to thrombocytopenia.

The bone marrow is hypercellular. Coagulation and platelet function abnormalities also have been found in patients with NCPF.

In a study by Bajaj et al. It shows a dilated and patent splenoportal axis.

Increased echogenicity of the walls of the portal vein is seen in NCPF. Doppler studies can help to identify any thrombus in the portal vein. Spontaneous splenorenal shunts are more common in NCPF compared to cirrhosis. Portal biliopathy is also seen in patients with NCPF. In cirrhosis, the colloid is not readily extracted by the liver due to fibrosis, but is taken up by the reticuloendothelial cells of the spleen and the bone marrow.

In contrast, in NCPF, there is no bone marrow shift as the liver parenchyma is normal.

The liver uptake is homogenous in NCPF, compared to patchy uptake in cirrhosis. The spleen uptake and the spleen size are significantly more in NCPF than in cirrhosis. Portovenography The classical portographic findings in NCPF include selective dilatation of the left branch of the portal vein with a sudden narrowing of major intrahepatic branches cut-off sign , paucity of medium-sized third and fourth order portal branches, obtuse-angled division of peripheral branches, avascular area beneath the liver surface, and intrahepatic collaterals.

The management of acute bleeding is similar to that of cirrhosis. There is no sufficient data on the efficacy of vasoactive drugs like octreotide and terlipressin in NCPF patients with acute variceal bleed. The preferred modality of treatment for acute variceal bleed is endoscopic therapy with either sclerotherapy or band ligation, both of which are effective in controlling acute bleeding in NCPF patients.

Primary and secondary prophylaxis for variceal bleeding Beta-blockers and endoscopic variceal ligation EVL Both beta-blockers and EVL are commonly used for primary prophylaxis of large esophageal varices in cirrhosis. In a study by Sarin et al. Studies have shown that prophylactic antibiotics reduce the variceal rebleeding and improve survival in patients with cirrhosis, but similar studies are lacking in patients with NCPF.

Shunt surgery In cirrhotic patients with portal hypertension, prophylactic portosystemic shunts have been found to be ineffective as deaths from post-shunt liver failure exceed those from bleeding. NCPF is generally considered to be a disease with benign prognosis.

But recent studies have shown that progressive liver failure can occur in NCPF also and some patients require liver transplantation. Cholangiopathy associated with portal hypertension: diagnostic evaluation and clinical implications. Gastrointest Endosc ;— Portal biliopathy. J Gastroenterol Hepatol ;— Bile duct varices or "pseudo-cholangiocarcinoma sign" in portal hypertension due to cavernous transformation of the portal vein.

Cholangiopathy in extrahepatic portal venous obstruction.

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Radiological appearances. Acta Radiol ;— Non-cirrhotic portal fibrosis idiopathic portal hypertension : experience with patients and a review of the literature.

Biliary abnormalities associated with extrahepatic portal venous obstruction. Hepatology ;— Portal cavernoma-associated cholangiopathy: a clinical and MR cholangiography coupled with MR portography imaging study.The authors found significant splenomegaly, persistent increase in portal pressure, and mild fibrosis without hepatic parenchymal injury, similar to NCPF in humans.

Gastrointest Endosc ; Magnetic resonance cholangiography features of biliary abnormalities due to cavernous transformation of the portal vein.

Perforators of common bile duct wall in portal hypertensive biliopathy (with videos)

This has been described as "obliterative portovenopathy" by Nayak and Ramalingaswamy. Abdominal infection at birth or in early childhood, umbilical sepsis, bacterial infections, and diarrheal episodes in infancy and early childhood are likely to lead to portal pyemia and pylephlebitis, which result in thrombosis, sclerosis, and obstruction of small- and medium-sized portal vein radicals.

There was no evidence of an atrial septal defect or other cardiac structural abnormality. EUS analysis of collateral veins inside and outside the esophageal wall in portal hypertension.